Associate Medical Director, Neurology Clinical Development

About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

STK-002 is Stoke’s proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Stoke’s initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach.

Position Purpose:

The Associate Medical Director, Neurology Clinical Development will contribute to the planning, execution, and interpretation of clinical studies for transformative therapies targeting life-threatening neurological diseases. This individual will provide medical and scientific to support one or more studies and play a hands-on role in study conduct, data review, and cross-functional clinical development activities.

The Associate Medical Director will work closely with and will report to the Senior Medical Director to help translate program strategy into high-quality clinical execution. This role is well suited for an individual who has strong foundational knowledge in clinical development and is ready to take on increasing responsibility in clinical document development, medical monitoring, supporting cross-functional teams, and interfacing with external partners and investigators to help ensure the highest standards of scientific and clinical rigor are maintained across the programs.

Key Responsibilities:

Clinical Development & Execution

• Contribute to the design, implementation, and oversight of clinical trials in neurology, including protocol development, study conduct, and data analysis
• Serve as a study-level medical monitor for assigned trials, with oversight from the Senior Medical Director
• Participate in ongoing medical review of eligibility, protocol deviations, and clinical data trends to support quality study conduct
• Draft and review key clinical documents (e.g. protocols, investigator brochures, clinical study reports, informed consent forms, medical monitoring plans, and sections of regulatory submissions)
• Collaborate with safety/pharmacovigilance on case review and signal evaluation
• Work closely with clinical development operations, data management, biostatistics, and regulatory colleagues to support study execution and timely delivery of milestones
• Maintain productive working relationships with CROs, investigators, and study site personnel to support enrollment, data quality, and protocol compliance
• Ensure adherence to GCP, ICH, and applicable regulatory and ethical requirements

Scientific Contribution

• Contribute clinical and scientific insight to study design discussions and broader program activities
• Review emerging clinical data, literature, and competitive intelligence to help inform study conduct and development decisions
• Support preparation of data summaries, internal presentations, and study-level recommendations for cross-functional review
• Contribute to the development and refinement of Clinical Development Plans and related program materials
• Assist in the preparation of regulatory documents, briefing packages, and health authority responses

External Engagement & Communication

• Interact with investigators, consultants, and key opinion leaders to support trial execution and scientific exchange
• Participate in investigator meetings, advisory board, and scientific congresses
• Contribute to the authorship of abstracts, manuscripts, and scientific presentations communicating clinical findings

Collaboration & Growth

• Operate as a strong cross-functional partner with a willingness to learn, adapt, and take on increasing scope
• Enhance clinical development judgment through active participation in study-team discussions and decision-making forums
• Contribute to a collaborative, scientifically rigorous team environment focused on patients and execution excellence

Required Skills & Experience:

• MD, MD/PhD, or PharmD candidates with relevant clinical development experience in neurology, rare/orphan, or genetic diseases
• Board certified or eligible in neurology, pediatrics, or a relevant specialty (for MDs)
• Minimum 3 years of relevant experience in clinical research, clinical development, or medical monitoring; biotech/pharmaceutical experience strongly preferred
• Experience supporting the conduct or medical oversight of interventional clinical trials
• Working knowledge of FDA/EMA regulations and ICH/GCP guidelines
• Strong scientific, analytical, and organizational skills, with careful attention to detail
• Ability to interpret complex clinical and scientific data and communicate findings clearly
• Effective collaborator who works well in a matrixed environment
• High personal integrity, sound judgment, and strong commitment to advancing therapies for patients with serious neurological diseases

Location(s):

Stoke operates in Bedford, MA. This position is a hybrid position with an office setting based in our Bedford, MA location.

Travel:

This position will require approximately 20% travel (domestic and international).

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role with an MD is $269,000 - $331,000 without MD the salary range is $242,000 - $273,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location.  In addition to base salary, Stoke offers an annual bonus and   equity participation.

Our benefits package includes medical, dental and vision insurance; life, long and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. 

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.