Provide scientific and strategic leadership for all in vivo pharmacology, efficacy, toxicology, and ADME/PK activities.
Lead pharmacology efforts across the full R&D continuum, from target validation and lead optimization through IND-enabling studies and early clinical development.
Design, interpret, and integrate pharmacology and toxicology data to inform candidate selection, dose selection, and clinical translation.
Partner closely with chemistry, biology, DMPK, CMC, regulatory, and clinical teams to ensure cohesive and efficient program advancement.
Ensure key activities are conducted in compliance with GLP and GMP regulations, as appropriate for stage of development.
Serve as a key contributor to IND filings, regulatory interactions, and development strategy.
Oversee and manage multiple CROs supporting outsourced pharmacology, toxicology, and ADME/PK activities, ensuring scientific quality, timelines, and budget adherence.
Build, mentor, and lead a high-performing team, fostering scientific rigor, collaboration, and accountability.
Establish best practices, workflows, and external partnerships to support program execution and portfolio advancement.
Present program strategy, data, and recommendations to internal and external review boards, and maintain close, ongoing communication with executive leadership and key stakeholders.
Provide scientific input to portfolio strategy, program reviews, and senior leadership decision-making.
Details of established essential functions for this position will be addressed/discussed during the interview process.
POSITION REQUIREMENTS:
PhD. in Pharmacology, Toxicology, Pharmaceutical Sciences, Cell Biology or a closely related field.
10+ years of experience in a pharmaceutical or biotechnology industry setting.
Demonstrated success advancing both small molecules and biologics through discovery, IND-enabling studies, and early clinical development.
Extensive hands-on and leadership experience in in vivo pharmacology, efficacy models, toxicology, and ADME/PK.
Proven ability to lead large, multidisciplinary teams and manage complex programs in a fast-paced R&D environment.
Strong working knowledge of GLP and GMP regulations and their application to preclinical and early clinical drug development.
Strong understanding of regulatory expectations for preclinical development and IND submission.
Proven experience managing multiple CROs and outsourced pharmacology programs.
Excellent scientific judgment, communication skills, and ability to influence across functions.
Prior experience in a senior leadership or executive-level role strongly preferred.
Ability to lead, inspire, and manage a large organization while maintaining hands-on scientific engagement.