Position Overview:
We are seeking a highly motivated and talented new PhD graduate to join our
Translational Medicine team as an Scientist. In this role, you will support early-stage translational strategies in oncology, autoimmune, and respiratory diseases, working alongside experienced leads on early programs and Global Project Teams (GPT). This is a growth-oriented role designed for a recent graduate with deep disease biology knowledge who is eager to learn how to translate scientific insights into drug development decisions—including patient selection strategies and companion diagnostic (CDx) exploration.
Core Responsibilities (with strong learning & growth components):
• Translational Strategy Support: As a contributing member of the project team, you will help support the development of integrated translational medicine strategies for early R&D, learning how to translate disease biology insights into testable clinical hypotheses under the guidance of senior team members.
• Scientific Direction & Patient Definition: Apply your foundational expertise in disease biology to contribute to the exploration of disease mechanisms. You will learn how to use translational research data to help define target patient populations, gaining hands-on experience in precision development strategies.
• Translational Research Execution: Contribute to the design and execution of key experiments to characterize mechanisms of action (MoA) and pharmacodynamics (PD). You will receive training and hands-on experience in developing and validating biomarkers for patient selection and efficacy assessment, as well as exposure to CDx development pathways.
• Cross-Functional Collaboration: Learn to serve as a translational science liaison, working closely with early discovery, clinical pharmacology, and clinical teams. You will develop skills in ensuring data continuity and effective integration across different stages of development.
• Decision Support: Learn how to generate and present core translational science data to support key program decisions, with mentorship on how to articulate the scientific logic from target to patient.
Qualifications (tailored for a graduating PhD):
• Education: PhD in a relevant field (e.g., Cancer Biology, Immunology, Respiratory Biology, Pharmacology, or a related discipline). Graduating or within 1 year of graduation.
• Foundational Expertise:
o Strong knowledge of disease biology in at least one of the following areas: oncology, autoimmune diseases, or respiratory diseases.
o Hands-on experience with basic biomarker or mechanistic research during graduate training (e.g., using techniques such as flow cytometry, IHC, ELISA, qPCR/dPCR, or NGS in a research setting).
o Familiarity with the concepts of MoA and PD studies (academic experience is sufficient).
• Eager to Learn: No prior industry experience required; however, you must demonstrate a strong interest in drug development, biomarker-driven patient selection strategies, and the overall translational medicine pipeline.
• Soft Skills: Strong analytical and problem-solving abilities, excellent communication skills, and a demonstrated ability to work collaboratively in a team environment.
职位概述：
我们正在寻找一位积极主动的 MD/PhD 转化医学科学家，作为早期项目或全球项目团队（GPT）的转化医学负责人，全面领导在肿瘤、自身免疫、呼吸系统疾病等领域的早期转化科学策略。您将负责制定并执行从临床前到早期临床阶段的整合转化计划，通过界定疾病机制与患者人群，驱动研发决策，并探索伴随诊断（CDx）的开发潜力。
核心职责：
转化策略领导： 作为项目核心成员，主导制定并执行早期研发阶段的整合性转化医学策略，将疾病生物学洞见转化为可验证的临床假设。
科学方向与患者界定： 基于对疾病生物学的深刻理解，主导目标疾病机制的探索，并运用转化研究数据科学界定潜在的目标患者人群，为精准开发策略奠定基础。
转化研究执行与整合： 设计并推动关键实验，以深入表征药物的作用机制（MoA）并进行药效动力学（PD）研究，开发及验证用于患者选择与药效评估的关键生物标志物，并评估其作为伴随诊断（CDx）的潜在可行性。
跨职能协作： 作为转化科学的核心接口，与早期发现团队、临床药理团队及临床团队紧密协作，确保转化策略在研发各阶段的有效整合与数据贯通。
决策支持： 为项目推进的关键决策提供核心转化科学依据，并清晰呈现从靶点到患者的科学逻辑。
任职要求：
教育背景： 拥有相关博士学位。
核心专长：
在肿瘤、自身免疫或呼吸系统疾病等领域具备扎实的疾病生物学知识和机制探索能力。
拥有领导或深度参与转化研究以支持早期药物开发决策的直接经验，熟悉利用生物标志物界定目标患者群体的策略。
精通生物标志物开发及MoA/PD研究，对伴随诊断（CDx）开发路径有了解者优先。
熟悉药物开发流程及早期临床试验设计。
经验背景： 在制药、生物技术行业或顶尖学术机构拥有数年在相关领域的转化医学或相关研究经验。具备项目领导或核心贡献者经验者优先。