Summer Intern - Formulation Development

Formulations Summer Intern

Summer Intern opportunity for Formulation Development team at Anagram Therapeutics in Natick, MA. The candidate will support hands-on formulation and analytical activities with a focus on analytical testing supporting formulation process development including blending, granulation and tableting. The candidate will execute experiments, analyze resulting materials, process analytical data and document procedures in lab notebook. During this period, the candidate will learn about the drug development process, enhance their laboratory skills, and gain experience in data collection, analysis and presentation.

Responsibilities:

The major responsibilities of this role are:

• Participate in the development of solid oral formulations for biotherapeutic modalities include enzyme-based therapies.
• Perform rapid and comprehensive characterization of candidate molecules to establish stability profiles and apply these insights to develop appropriate formulation prototypes. This work will utilize a broad range of analytical techniques including standard analytical tests for solid oral dosage forms (e.g. but not limited to dissolution, disintegration testing, friability testing, OM, SEM, RP-HPLC, sieving analysis, powder flow characterization, pre-formulation and solid-state characterization studies)
• Assist in formulation development (bench top) and as required, support tech transfer to CDMO’s
• Drug product processes may include fluid handling, spray drying, granulation, tableting, milling, sieving, etc.
• Generate lab prototype formulations by utilizing advanced in-house and external technologies (solid dispersions, etc.) to enhance stability, solubility and manufacturability.
• Participate in formulation process development activities, dissolution studies and selection of packaging configuration. Support management of activities at external development and technology scouting partners/vendors
• Design and interpret stability studies using ICH and ASAP techniques
• Prepare technical reports, protocols, internal updates for team review and reference
• Champion opportunities to introduce enabling technologies for process improvements and develop best practices
• Conduct experiments and record in lab notebooks
• Analyze data collected from experiments and present results to team
• Develop and document best practices for experiments
• Create a final presentation to present to wider team

Qualifications:

Basic Qualifications:

• Currently enrolled student working towards undergraduate or graduate degree in chemistry, pharmacy, biotech, pharmaceutical sciences or related field, with a particular interest in formulation development and analytical testing.
• Hands on-analytical experience is a must.

A successful candidate should have the following:

• Strong written and oral communication
• Detail oriented, organized and excellent time management skills
• Eagerness to learn and a collaborative team member
• Proficient in MS Office application (Word/excel/PowerPoint)
• Critical thinking and nimble problem-solving abilities
• Ability to drive locally in MA to CDMO/CRO to oversee activities (some travel is expected to support work across partner sites or CDMO/CRO network
• This is a lab-based position and incumbent must be able to perform all lab-based duties (may include occasionally lifting less than 25 lbs. in lab)

Preferred Qualification

• Hands on lab experience with a variety of analytical techniques
• Knowledge and experience in developing amorphous solid dispersions is an advantage
• Expertise in pre-formulation, manufacturing and advanced delivery technologies