Senior Associate Scientist

Job description

We are seeking a talented and experienced Scientist II who will conduct protein purification and analytics to support development of protein biotherapeutics in a fast-paced research environment. This person will be primarily responsible for executing protein production on standardized screening protein methods to enable AI/ML. This person will also be responsible for analytics as well as, analyzing and interpreting assays and production data to understand inherent protein attributes and physicochemical stability. The ideal candidate will be a quick learner who takes the initiative with enthusiasm and resourcefulness; an effective collaborator who works within the team to enhance project knowledge.

• Perform purification of biotherapeutic proteins using standard chromatography methods (Affinity capture, SEC, CEX, AEX, MMC, HIC). Experience preferred.
• Perform standard analytical techniques to assess protein purity, stability and quality (HPLC-SEC, SDS-PAGE, CGE, DLS). Experience preferred.
• Perform stage appropriate purification assessments, including screening of protein behaviors and attributes in relevant process conditions.
• Contribute to broader research goals in areas related to protein biochemistry aimed at developing a better understanding of therapeutic protein structure, stability, dynamics, and function.
• Provide protein biochemistry and protein purification support for other scientists across Biotherapeutics Discovery; perform other tasks as assigned by manager in a timely manner.
• Improve data quality, consistency, and throughput using automation and analysis scripts. Identify opportunities for innovative automation strategies to streamline operations and boost workflow efficiency.
• Comply with all applicable regulations, perform all work in a safe manner; maintain proper records in accordance with SOP’s and policies.
• Experience with data analysis software and/or modern computer programming languages (MATLAB, Mathematica, Python, SQL, or Java); experience in statistical and DOE software (JMP, R, Minitab, Statistica) is beneficial.
• Familiarity with lab automation is preferred.
• Strong grasp of protein biochemistry principles underpinning protein interactions, stability, and biotherapeutic quality attributes.
• Creative problem solving with a high level of initiative and ability to work independently as well as collaboratively
• Good record-keeping and organizational skills with exceptional attention to detail.
• Excellent writing, presenting, and communicating skills.

Education

• Bachelor’s Degree from an accredited institution with three-plus (3+) years of experience in biochemistry or related scientific discipline or Master’s Degree from an accredited institution in related scientific discipline or equivalent experience in related field.