Principal Scientist, Peptide Chemistry

About the Company

A soon to launch Third Rock Ventures company is seeking an experienced Peptide Scientist to lead peptide design efforts supporting discovery-stage therapeutic programs. This role will focus on peptide SAR, data interpretation, and lead optimization, working closely with project leadership and cross-functional teams.

Responsibilities

• Lead and design strategies for peptide therapeutics to support early discovery programs
• Drive structure–activity relationship (SAR) efforts and guide molecule optimization
• Manage and oversee work conducted at external CRO partners, including peptide synthesis, analytics, and related studies
• Review and interpret experimental data to inform molecule design and program strategy
• Present program updates and recommendations to project teams
• Partner closely with project leads and cross-functional teams (biology, pharmacology, DMPK, CMC) to advance programs
• Help define external study plans, timelines, and priorities to support program milestones

Qualifications

• PhD in chemistry, chemical biology, peptide science, or related field
• Significant experience in therapeutic peptide discovery
• Expertise in metabolic or endocrine indications
• Demonstrated ability to guide molecule design and SAR strategy
• Track record of contributing to advancement of discovery programs
• Experience managing external CRO collaborations
• Strong communication skills and ability to present scientific strategy to multidisciplinary teams

Required Skills

• Experience in therapeutic peptide discovery and optimization
• Ability to guide peptide design and SAR strategy
• Strong communication skills
• Experience managing external CRO collaborations
• Ability to present scientific strategy to multidisciplinary teams

Location

• With offices in Boston, San Francisco and Shanghai, the ability to work from one of these locations, but we are open to remote employment for exceptional individuals able to work collaboratively and effectively

Equal Opportunity Statement

We are committed to diversity and inclusivity.