Position Overview
We are looking for a highly motivated PhD-level scientist with strong laboratory expertise to contribute to a priority research initiative focused on understanding cancer biology mechanisms through advanced cellular and molecular approaches. This role demands technical depth, critical thinking, and a hands-on approach to experimental science.
The individual in this position will collaborate with a cross-functional team to investigate the biology of a novel target and support small-molecule drug discovery efforts. This is a strong opportunity to play a key role in early-stage scientific discovery within oncology. Title and level will be determined based on experience.
Key Responsibilities
- Design, execute, and troubleshoot in vitro experiments to evaluate target biology, pathway activity, and drug mechanism of action
- Conduct cell-based assays incorporating gene knockdown/knockout (siRNA, shRNA, CRISPR), overexpression systems, and pharmacologic modulation
- Utilize a range of molecular and cellular biology techniques to study signaling pathways, protein trafficking, immune-related responses, and genetic interactions
- Analyze and interpret experimental data with a focus on accuracy, reproducibility, and mechanistic understanding
- Collaborate closely with project teams to ensure experimental strategies align with broader research and therapeutic goals
- Present data and insights effectively in team settings and contribute to ongoing program direction and planning
Qualifications
- PhD in cancer biology, molecular biology, cell biology, or a related scientific discipline
- Postdoctoral training or 4–8 years of industry experience is preferred
- Proven ability to independently design and carry out hypothesis-driven research
- Strong background in mammalian cell culture, viability/proliferation assays, and flow cytometry
- Hands-on experience with techniques such as qRT-PCR, RNA isolation, Western blotting, ELISA, HTRF, MSD, and confocal microscopy
- Experience with functional genomics approaches and assay development for studying protein function, degradation, trafficking, or immune signaling is highly valued
- Strong analytical skills with the ability to integrate data from multiple experimental platforms
- Familiarity with data analysis and visualization tools is a plus
- Experience working with external partners or CROs is beneficial
Ideal Profile
- Demonstrates scientific curiosity paired with a results-oriented mindset
- Thrives in a fast-paced, early-stage research environment
- Adaptable and comfortable navigating evolving scientific challenges
- Effective communicator who collaborates well across teams and contributes to a positive, accountable, and high-performance culture