Downstream Scientist

Title: Sr. Scientist (Downstream)

Location: Swiftwater, PA

Duration: 12+ months (Temp to Hire)

Schedule: M-F 8am to 5pm

The Downstream Process Development, MSAT department supports several projects including:

• Seasonal strain changes for Flublok/Covid Vaccine
• Process improvement and optimization projects
• Yield improvement strategies and implementation
• Process monitoring and control
• Manufacturing support for production operations

Responsibilities:

• Primary responsibilities are the execution of development studies such as resin reuse, process improvements, optimization, scale-up, column load, and evaluation of yield improvement strategies as outlined by the Deputy Director DSP/MSAT in collaboration with others on projects.
• Executes purification experiments including automated or high-throughput chromatography (AKTA platform), filtration, clarification/ depth filtration, column packing, and tangential flow filtration independently based on expert knowledge of protein purification and analysis with an in-depth understanding of all modes of chromatography.
• Makes detailed observations, analyzes data, and interprets results.
• Exercise technical discretion in the design, execution, and interpretation of experiments that contribute to projects.
• Prepares technical reports, summaries, protocols, and quantitative analyses.
• Responsible for training on, understanding, and following documented procedures that apply to their departments.
• Responsible for general lab maintenance.

Qualifications:

• Proactively anticipates and effectively communicates successes, constraints, solutions, and actions for resolution.
• Fosters relationships with partners, experts from other functions, and customers to achieve technical objectives.
• Perform troubleshooting as required and supports staff.
• Demonstrate and promote company values and competencies through daily actions and decisions.
• Contribute to strategic planning for downstream process development initiatives.

Basic Qualifications:

• Bachelor’s or master's in biology, Biomedical, Biotechnology, Biochemistry, or similar discipline.
• Years of Experience: 2 - 6 Years

Preferred Qualifications:

• Operating, maintaining, and troubleshooting chromatography workstations and process skids.
• Analyzing Data with Assay (SDS PAGE and Western Blot, SRID, BCA, Purity, Dialysis for rBV, ELISA, etc.)
• Knowledge and experience working with automated high throughput process development equipment.
• Demonstrates working knowledge of scientific principles and concerns.
• Participates in quality control tracking systems including change controls, deviations, CAPA, root cause analysis, etc.
• Maintains project timelines.
• Good documentation practices (GDP).
• Experience in writing standard operating procedures (SOP), batch records, and reports.
• Hands-on experience with molecular modeling software is desirable but not required.