Scientist

Title : Scientist

Location: Ridgefield, CT

Contract Duration : 12 Months contract

PURPOSE OF THE JOB:

• Plan, coordinate and perform purification of biotherapeutic proteins using standard chromatography methods (Affinity capture, SEC, CEX, AEX, MMC, HIC). Troubleshoot complex systems as necessary through process development.
• Perform standard analytical techniques to assess protein purity, stability and quality (HPLC-SEC, SDS-PAGE, CGE, DLS)
• Evaluate new technologies and process changes to improve the productivity, quality and consistency of standard platform processes.
• Perform stage appropriate purification assessments, including screening of protein behaviors and attributes in relevant process conditions, interpret and present findings to other Biotherapeutics Discovery colleagues.
• Develop novel analytical methodologies and evaluate new technologies to improve purification team capabilities
• Contribute to broader research goals in areas related to protein biochemistry aimed at developing a better understanding of therapeutic protein structure, stability, dynamics, and function.
• Provide protein biochemistry and protein purification support for other scientists across Biotherapeutics Discovery; perform other tasks as assigned by manager in a timely manner.
• Improve data quality, consistency, and throughput using automation and analysis scripts. Identify opportunities for innovative automation strategies to streamline operations and boost workflow efficiency.
• Comply with all applicable regulations, perform all work in a safe manner; maintain proper records in accordance with SOP’s and policies.

Skills:

• Thorough understanding of cell culture basics.
• Hands-on experience in cell culture (mammalian) and exceptional aseptic techniques.
• Strong attention to details and excellent organizational skills.
• Able to learn quickly and excel in a past-faced work environment; self-motivation, adaptability and positive attitude.
• Hands-on experience in handling automation/HTP antibody expression is a plus
• Ability to work in plate based formats (24 well, 96 well)
• Knowledge of DNA and molecular biology including basic DNA quality assessments
• Apply knowledge of basic theory and scientific principles
• Concise and accurate reporting of technical data and information
• Ability to troubleshoot and multi-task
• Ability to work in team-oriented environment
• Excellent written and verbal communication skills

Education:

Master’s Degree from an accredited institution with three-plus (3+) years of experience in related scientific discipline, OR Bachelor’s Degree from an accredited institution with seven-plus (7+) years of experience in related scientific discipline or equivalent experience in related field